An October 2005 panel discussion at Vanderbilt addressed the role of reason and faith in the pursuit of science and understanding the place of humanity in the world. Father Edward Malloy, PhD'75, president emeritus of the University of Notre Dame, and Vanderbilt faculty from several disciplines were asked to address the current battles over evolution prompted by advocates of intelligent design. Included in this article are edited versions of the five panelists' remarks. Each was free to view the constraints, challenges and opportunities posed by the intersection of religion and critical inquiry from her or his own particular perspective.